Distinct energetics and closing pathways for DNA polymerase beta with 8-oxoG template and different...
Distinct energetics and closing pathways for DNA polymerase beta with 8-oxoG template and different incoming nucleotides
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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Contents
8-Oxoguanine (8-oxoG) is a common oxidative lesion frequently encountered by DNA polymerases such as the repair enzyme DNA polymerase beta (pol beta). To interpret in atomic and energetic detail how pol beta processes 8-oxoG, we apply transition path sampling to delineate closing pathways of pol beta 8-oxoG complexes with dCTP and dATP incoming nuc...
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Full title
Distinct energetics and closing pathways for DNA polymerase beta with 8-oxoG template and different incoming nucleotides
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1819382
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1819382
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ISSN
1472-6807
E-ISSN
1472-6807
DOI
10.1186/1472-6807-7-7
