Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction an...
Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress
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Publisher
National Academy of Sciences
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Language
English
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Publisher
National Academy of Sciences
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Contents
Increased production of reactive oxygen species (ROS) and loss of endothelial NO bioavailability are key features of vascular disease in diabetes mellitus. The p66Shc adaptor protein controls cellular responses to oxidative stress. Mice lacking p66Shc (p66Shc⁻/⁻) have increased resistance to ROS and prolonged life span. The present work was designe...
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Full title
Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1829289
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1829289
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0609656104
