Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mech...
Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Reelin, a large secreted protein implicated in the cortical development of the mammalian brain, is composed of eight tandem concatenations of "reelin repeats" and binds to neuronal receptors belonging to the low-density lipoprotein receptor gene family. We found that both receptor-binding and subsequent Dab1 phosphorylation occur solely in the segm...
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Full title
Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1891246
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1891246
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0700438104