Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 ge...
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
About this item
Full title
Author / Creator
Deichmann, Annette , Hacein-Bey-Abina, Salima , Schmidt, Manfred , Garrigue, Alexandrine , Brugman, Martijn H , Hu, Jingqiong , Glimm, Hanno , Gyapay, Gabor , Prum, Bernard , Fraser, Christopher C , Fischer, Nicolas , Schwarzwaelder, Kerstin , Siegler, Maria-Luise , de Ridder, Dick , Pike-Overzet, Karin , Howe, Steven J , Thrasher, Adrian J , Wagemaker, Gerard , Abel, Ulrich , Staal, Frank J T , Delabesse, Eric , Villeval, Jean-Luc , Aronow, Bruce , Hue, Christophe , Prinz, Claudia , Wissler, Manuela , Klanke, Chuck , Weissenbach, Jean , Alexander, Ian , Fischer, Alain , von Kalle, Christof and Cavazzana-Calvo, Marina
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Recent reports have challenged the notion that retroviruses and retroviral vectors integrate randomly into the host genome. These reports pointed to a strong bias toward integration in and near gene coding regions and, for gammaretroviral vectors, around transcription start sites. Here, we report the results obtained from a large-scale mapping of 5...
Alternative Titles
Full title
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
Authors, Artists and Contributors
Author / Creator
Hacein-Bey-Abina, Salima
Schmidt, Manfred
Garrigue, Alexandrine
Brugman, Martijn H
Hu, Jingqiong
Glimm, Hanno
Gyapay, Gabor
Prum, Bernard
Fraser, Christopher C
Fischer, Nicolas
Schwarzwaelder, Kerstin
Siegler, Maria-Luise
de Ridder, Dick
Pike-Overzet, Karin
Howe, Steven J
Thrasher, Adrian J
Wagemaker, Gerard
Abel, Ulrich
Staal, Frank J T
Delabesse, Eric
Villeval, Jean-Luc
Aronow, Bruce
Hue, Christophe
Prinz, Claudia
Wissler, Manuela
Klanke, Chuck
Weissenbach, Jean
Alexander, Ian
Fischer, Alain
von Kalle, Christof
Cavazzana-Calvo, Marina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1934585
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1934585
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/jci31659
