PPARα activation is essential for HCV core protein–induced hepatic steatosis and hepatocellular carc...
PPARα activation is essential for HCV core protein–induced hepatic steatosis and hepatocellular carcinoma in mice
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Publisher
American Society for Clinical Investigation
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Language
English
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Publisher
American Society for Clinical Investigation
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Scope and Contents
Contents
Transgenic mice expressing HCV core protein develop hepatic steatosis and hepatocellular carcinoma (HCC), but the mechanism underlying this process remains unclear. Because PPARα is a central regulator of triglyceride homeostasis and mediates hepatocarcinogenesis in rodents, we determined whether PPARα contributes to HCV core protein--induced disea...
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Full title
PPARα activation is essential for HCV core protein–induced hepatic steatosis and hepatocellular carcinoma in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2176192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2176192
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI33594
