Conformational changes in G‐protein‐coupled receptors—the quest for functionally selective conformat...
Conformational changes in G‐protein‐coupled receptors—the quest for functionally selective conformations is open
About this item
Full title
Author / Creator
Hoffmann, C , Zürn, A , Bünemann, M and Lohse, M J
Publisher
Oxford, UK: Blackwell Publishing Ltd
Journal title
Language
English
Formats
Publication information
Publisher
Oxford, UK: Blackwell Publishing Ltd
Subjects
More information
Scope and Contents
Contents
The G‐protein‐coupled receptors (GPCRs) represent one the largest families of drug targets. Upon agonist binding a receptor undergoes conformational rearrangements that lead to a novel protein conformation which in turn can interact with effector proteins. During the last decade significant progress has been made to prove that different conformatio...
Alternative Titles
Full title
Conformational changes in G‐protein‐coupled receptors—the quest for functionally selective conformations is open
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2268050
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2268050
Other Identifiers
ISSN
0007-1188
E-ISSN
1476-5381
DOI
10.1038/sj.bjp.0707615
