catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the t...
catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The evolution of new catalytic activities and specificities within an enzyme superfamily requires the exploration of sequence space for adaptation to a new substrate with retention of those elements required to stabilize key intermediates/transition states. Here, we propose that core residues in the large enzyme family, the haloalkanoic acid dehalo...
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Full title
catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2311376
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2311376
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0710800105
