Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism...
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid
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Author / Creator
Máximo, V , Botelho, T , Capela, J , Soares, P , Lima, J , Taveira, A , Amaro, T , Barbosa, A P , Preto, A , Harach, H R , Williams, D and Sobrinho-Simões, M
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Oxyphil or Hürthle cell tumours of the thyroid are characterised by their consistent excessive number of mitochondria. A recently discovered gene,
GRIM-19
has been found to fulfil two roles within the cell: as a member of the interferon-
β
and retinoic acid-induced pathway of cell death, and as part of the mitochondrial Complex I assemb...
Alternative Titles
Full title
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2361763
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2361763
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/sj.bjc.6602547
