ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
About this item
Full title
Author / Creator
Yang, Jer-Yen , Zong, Cong S. , Xia, Weiya , Yamaguchi, Hirohito , Ding, Qingqing , Xie, Xiaoming , Lang, Jing-Yu , Lai, Chien-Chen , Chang, Chun-Ju , Huang, Wei-Chien , Huang, Hsin , Kuo, Hsu-Ping , Lee, Dung-Fang , Li, Long-Yuan , Lien, Huang-Chun , Cheng, Xiaoyun , Chang, King-Jen , Hsiao, Chwan-Deng , Tsai, Fuu-Jen , Tsai, Chang-Hai , Sahin, Aysegul A. , Muller, William J. , Mills, Gordon B. , Yu, Dihua , Hortobagyi, Gabriel N. and Hung, Mien-Chie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The RAS–ERK pathway is known to play a pivotal role in differentiation, proliferation and tumour progression. Here, we show that Erk downregulates Forkhead box O 3a (FOXO3a) by directly interacting with and phosphorylating FOXO3a at Ser 294, Ser 344 and Ser 425, which consequently promotes cell proliferation and tumorigenesis. The ERK-phosphorylate...
Alternative Titles
Full title
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Authors, Artists and Contributors
Author / Creator
Zong, Cong S.
Xia, Weiya
Yamaguchi, Hirohito
Ding, Qingqing
Xie, Xiaoming
Lang, Jing-Yu
Lai, Chien-Chen
Chang, Chun-Ju
Huang, Wei-Chien
Huang, Hsin
Kuo, Hsu-Ping
Lee, Dung-Fang
Li, Long-Yuan
Lien, Huang-Chun
Cheng, Xiaoyun
Chang, King-Jen
Hsiao, Chwan-Deng
Tsai, Fuu-Jen
Tsai, Chang-Hai
Sahin, Aysegul A.
Muller, William J.
Mills, Gordon B.
Yu, Dihua
Hortobagyi, Gabriel N.
Hung, Mien-Chie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2376808
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2376808
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb1676
