Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation
Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation
About this item
Full title
Author / Creator
Florl, A R , Steinhoff, C , Müller, M , Seifert, H-H , Hader, C , Engers, R , Ackermann, R and Schulz, W A
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
In prostate carcinoma (PCa) increased DNA methylation (‘hypermethylation’) occurs at specific genes such as
GSTP1
. Nevertheless, overall methylation can be decreased (‘hypomethylation’) because methylation of repetitive sequences like LINE-1 retrotransposons is diminished. We analysed DNA from 113 PCa and 36 noncancerous prostate tissues for...
Alternative Titles
Full title
Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2409889
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2409889
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/sj.bjc.6602030
