CD73 is required for efficient entry of lymphocytes into the central nervous system during experimen...
CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
CD73 is a cell surface enzyme of the purine catabolic pathway that catalyzes the breakdown of AMP to adenosine. Because of the strong immunosuppressive and antiinflammatory properties of adenosine, we predicted that cd73⁻/⁻ mice would develop severe experimental autoimmune encephalomyelitis (EAE), an animal model for the central nervous system (CNS...
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Full title
CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2453691
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2453691
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0711175105
