Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of...
Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1
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Author / Creator
Publisher
New York, NY: Am Thoracic Soc
Journal title
Language
English
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Publisher
New York, NY: Am Thoracic Soc
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Scope and Contents
Contents
Oxidative stress is a key contributor in chronic obstructive pulmonary disease (COPD) pathogenesis caused by cigarette smoking. NRF2, a redox-sensitive transcription factor, dissociates from its inhibitor, KEAP1, to induce antioxidant expression that inhibits oxidative stress.
To determine the link between severity of COPD, oxidative stress, and...
Alternative Titles
Full title
Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2542433
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2542433
Other Identifiers
ISSN
1073-449X,1535-4970
E-ISSN
1535-4970
DOI
10.1164/rccm.200803-380OC
