Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons
Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons
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Author / Creator
Li, Hongmei , Chen, Yingbei , Jones, Adrienne F , Sanger, Richard H , Collis, Leon P , Flannery, Richard , McNay, Ewan C , Yu, Tingxi , Schwarzenbacher, Robert , Bossy, Blaise , Bossy-Wetzel, Ella , Bennett, Michael V.L , Pypaert, Marc , Hickman, John A , Smith, Peter J.S , Hardwick, J. Marie and Jonas, Elizabeth A
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Maturation of neuronal synapses is thought to involve mitochondria. Bcl-xL protein inhibits mitochondria-mediated apoptosis but may have other functions in healthy adult neurons in which Bcl-xL is abundant. Here, we report that overexpression of Bcl-xL postsynaptically increases frequency and amplitude of spontaneous miniature synaptic currents in...
Alternative Titles
Full title
Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2542873
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2542873
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0711647105
