Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refrac...
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis
About this item
Full title
Author / Creator
Nguyên, Thi Lien-Anh , Abdelbary, Hesham , Arguello, Meztli , Breitbach, Caroline , Leveille, Simon , Diallo, Jean-Simon , Yasmeen, Amber , Bismar, Tarek A , Kirn, David , Falls, Theresa , Snoulten, Valerie E , Vanderhyden, Barbara C , Werier, Joel , Atkins, Harold , Vähä-Koskela, Markus J.V , Stojdl, David F , Bell, John C and Hiscott, John
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Intratumoral innate immunity can play a significant role in blocking the effective therapeutic spread of a number of oncolytic viruses (OVs). Histone deacetylase inhibitors (HDIs) are known to influence epigenetic modifications of chromatin and can blunt the cellular antiviral response. We reasoned that pretreatment of tumors with HDIs could enhanc...
Alternative Titles
Full title
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis
Authors, Artists and Contributors
Author / Creator
Abdelbary, Hesham
Arguello, Meztli
Breitbach, Caroline
Leveille, Simon
Diallo, Jean-Simon
Yasmeen, Amber
Bismar, Tarek A
Kirn, David
Falls, Theresa
Snoulten, Valerie E
Vanderhyden, Barbara C
Werier, Joel
Atkins, Harold
Vähä-Koskela, Markus J.V
Stojdl, David F
Bell, John C
Hiscott, John
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2567479
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2567479
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0803988105
