Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
About this item
Full title
Author / Creator
Sonveaux, Pierre , Végran, Frédérique , Schroeder, Thies , Wergin, Melanie C. , Verrax, Julien , Rabbani, Zahid N. , De Saedeleer, Christophe J. , Kennedy, Kelly M. , Diepart, Caroline , Jordan, Bénédicte F. , Kelley, Michael J. , Gallez, Bernard , Wahl, Miriam L. , Feron, Olivier and Dewhirst, Mark W.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradient that mirrors the oxygen gradient in the tumor. By contrast, oxygenated tumor cells have been thought to primarily use glucose fo...
Alternative Titles
Full title
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2582933
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2582933
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI36843
