Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The contribution of fatty acids to Alzheimer's disease pathogenesis is unclear. The authors identify an increase in arachadonic acid and its metabolites in a mouse model for Alzheimer's disease and show that amyloid-beta (Aβ) affects phosphorylation of an isoform of phospholipase A
2
(GIVA-PLA
2
). Inhibiting activation of GIVA-PLA
2...
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Full title
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2597064
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2597064
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.2213
