Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse p...
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes
About this item
Full title
Author / Creator
Girard, Christophe A. , Wunderlich, F. Thomas , Shimomura, Kenju , Collins, Stephan , Kaizik, Stephan , Proks, Peter , Abdulkader, Fernando , Clark, Anne , Ball, Vicky , Zubcevic, Lejla , Bentley, Liz , Clark, Rebecca , Church, Chris , Hugill, Alison , Galvanovskis, Juris , Cox, Roger , Rorsman, Patrik , Brüning, Jens C. and Ashcroft, Frances M.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Neonatal diabetes is a rare monogenic form of diabetes that usually presents within the first six months of life. It is commonly caused by gain-of-function mutations in the genes encoding the Kir6.2 and SUR1 subunits of the plasmalemmal ATP-sensitive K+ (KATP) channel. To better understand this disease, we generated a mouse expressing a Kir6.2 muta...
Alternative Titles
Full title
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes
Authors, Artists and Contributors
Author / Creator
Wunderlich, F. Thomas
Shimomura, Kenju
Collins, Stephan
Kaizik, Stephan
Proks, Peter
Abdulkader, Fernando
Clark, Anne
Ball, Vicky
Zubcevic, Lejla
Bentley, Liz
Clark, Rebecca
Church, Chris
Hugill, Alison
Galvanovskis, Juris
Cox, Roger
Rorsman, Patrik
Brüning, Jens C.
Ashcroft, Frances M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2613450
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2613450
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI35772
