The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Ubiquitin-dependent degradation of Cdc20 by the APC/C ligase is a conserved mechanism essential for maintaining the spindle assembly checkpoint activated by unattached chromosomes.
The spindle assembly checkpoint (SAC) is required to block sister chromatid separation until all chromosomes are properly attached to the mitotic apparatus. The SAC p...
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The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2635557
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2635557
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb1799
