Crystal structure of human CDK4 in complex with a D-type cyclin
Crystal structure of human CDK4 in complex with a D-type cyclin
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The cyclin D1-cyclin-dependent kinase 4 (CDK4) complex is a key regulator of the transition through the G₁ phase of the cell cycle. Among the cyclin/CDKs, CDK4 and cyclin D1 are the most frequently activated by somatic genetic alterations in multiple tumor types. Thus, aberrant regulation of the CDK4/cyclin D1 pathway plays an essential role in onc...
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Full title
Crystal structure of human CDK4 in complex with a D-type cyclin
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2657441
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2657441
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0809645106
