Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
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Author / Creator
Gerken, Thomas , Girard, Christophe A , Tung, Yi-Chun Loraine , Webby, Celia J , Saudek, Vladimir , Hewitson, Kirsty S , Yeo, Giles S.H , McDonough, Michael A , Cunliffe, Sharon , McNeill, Luke A , Galvanovskis, Juris , Rorsman, Patrik , Robins, Peter , Prieur, Xavier , Coll, Anthony P , Ma, Marcella , Jovanovic, Zorica , Farooqi, I. Sadaf , Sedgwick, Barbara , Barroso, Inês , Lindahl, Tomas , Ponting, Chris P , Ashcroft, Frances M , O'Rahilly, Stephen and Schofield, Christopher J
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
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More information
Scope and Contents
Contents
Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate-dependent oxygenases. We find that recombinant murine Fto catalyzes the Fe(II)- and 2OG-dependent demethylation of 3-methylthymin...
Alternative Titles
Full title
Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
Authors, Artists and Contributors
Author / Creator
Girard, Christophe A
Tung, Yi-Chun Loraine
Webby, Celia J
Saudek, Vladimir
Hewitson, Kirsty S
Yeo, Giles S.H
McDonough, Michael A
Cunliffe, Sharon
McNeill, Luke A
Galvanovskis, Juris
Rorsman, Patrik
Robins, Peter
Prieur, Xavier
Coll, Anthony P
Ma, Marcella
Jovanovic, Zorica
Farooqi, I. Sadaf
Sedgwick, Barbara
Barroso, Inês
Lindahl, Tomas
Ponting, Chris P
Ashcroft, Frances M
O'Rahilly, Stephen
Schofield, Christopher J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2668859
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2668859
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1151710
