Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-cate...
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Andrzej Dlugosz and colleagues report that Hedgehog-dependent skin tumors require canonical Wnt signaling for their development.
Constitutive Hedgehog (Hh) signaling underlies several human tumors
1
, including basal cell carcinoma (BCC) and basaloid follicular hamartoma in skin
2
,
3
. Intriguingly, superficial BCCs arise as
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Full title
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2688690
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2688690
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.192
