Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Histones and leukaemia
A chromosomal translocation found in certain acute myeloid leukaemia (AML) patients results in fusion of the PHD finger of a chromatin-binding protein to a nucleoporin NUP98. One such fusion protein is now reported to be a potent oncoprotein inducing AML. Introducing mutations in the PHD finger that abrogate its binding to...
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Full title
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2697266
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2697266
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature08036
