Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosph...
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates
About this item
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Author / Creator
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publication information
Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
In acute inflammation, extracellular ATP activates P2X
7
ion channel receptors (P2X
7
R) on M1 polarized macrophages to release pro‐inflammatory IL‐1β through activation of the caspase‐1/nucleotide‐binding domain and leucine‐rich repeat receptor containing pyrin domain 3 (NLRP3) inflammasome. In contrast, M2 polarized macrophages are cr...
Alternative Titles
Full title
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2699392
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2699392
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2009.163
