The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene e...
The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice
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Publisher
United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Down syndrome critical region gene 1 (DSCR-1) short variant (DSCR-1s) is an inhibitor of calcineurin/NFAT signaling encoded by exons 4-7 of DSCR1. We previously reported that VEGF induces DSCR-1s expression in endothelial cells, which in turn negatively feeds back to attenuate endothelial cell activation. Here, in order to characterize the role of...
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Full title
The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2719921
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2719921
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI35738
