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Proteasomal Regulation of the Hypoxic Response Modulates Aging in C.elegans

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Proteasomal Regulation of the Hypoxic Response Modulates Aging in C.elegans

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2737476

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C.elegans

About this item

Full title

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C.elegans

Author / Creator

Mehta, Ranjana , Steinkraus, Katherine A. , Sutphin, George L. , Ramos, Fresnida J. , Shamieh, Lara S. , Huh, Alexander , Davis, Christina , Chandler-Brown, Devon and Kaeberlein, Matt

Journal title

Science (American Association for the Advancement of Science), 2009-04, Vol.324 (5931), p.1196-1198

Language

English

Formats

Articles

More information

Scope and Contents

Contents

The
Caenorhabditis elegans
von Hippel-Lindau tumor suppressor homolog VHL-1 is a cullin E3 ubiquitin ligase that negatively regulates the hypoxic response by promoting ubiquitination and degradation of the hypoxic response transcription factor HIF-1. Here we report that loss of VHL-1 significantly increased lifespan and enhanced resistance to...

Alternative Titles

Full title

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C.elegans

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2737476

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2737476

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.1173507

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