BACE1 regulates voltage-gated sodium channels and neuronal activity
BACE1 regulates voltage-gated sodium channels and neuronal activity
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
BACE1 activity is significantly increased in the brains of Alzheimer's disease patients, potentially contributing to neurodegeneration. The voltage-gated sodium channel (Na
v
1) β2-subunit (β2), a type I membrane protein that covalently binds to Na
v
1 α-subunits, is a substrate for BACE1 and γ-secretase. Here, we find that BACE1–γ-secr...
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Full title
BACE1 regulates voltage-gated sodium channels and neuronal activity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2747787
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2747787
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb1602
