Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Prion link to Alzheimer's
The hypothesis that soluble amyloid-β peptide oligomer plays a central role in Alzheimer's disease is well established, yet no mechanistic basis for Aβ oligomer effects on neurons has been described. Several lines of evidence point to the existence of a high-affinity cell-surface receptor for soluble Aβ oligomers on neu...
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Full title
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2748841
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2748841
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature07761
