Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor a...
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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The promise of engineered T cells for treating cancer has been mitigated by their poor persistence when transferred to patients. Pule
et al
. now show that dual-specific T cells that recognize an Epstein-Barr virus (EBV) antigen and a tumor antigen survive longer in individuals with neuroblastoma. Engineering virus-specific T cells to recogni...
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Full title
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2749734
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2749734
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.1882
