Inhibition of a viral enzyme by a small-molecule dimer disruptor
Inhibition of a viral enzyme by a small-molecule dimer disruptor
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
We identified small-molecule dimer disruptors that inhibit an essential dimeric protease of human Kaposi's sarcoma–associated herpesvirus (KSHV) by screening an α-helical mimetic library. Next, we synthesized a second generation of low-micromolar inhibitors with improved potency and solubility. Complementary methods including size exclusion chromat...
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Full title
Inhibition of a viral enzyme by a small-molecule dimer disruptor
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2752665
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2752665
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.192
