Nicotine binding to brain receptors requires a strong cation–π interaction
Nicotine binding to brain receptors requires a strong cation–π interaction
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Nicotine's double life
Nicotine's remarkable propensity for inducing addiction starts with its ability to bind to brain acetylcholine (ACh) receptors with high affinity. If it activated the ACh receptors in muscle, nearly identical to those in the brain, with similar efficiency, smoking would cause severe muscle contractions. That this doesn't h...
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Nicotine binding to brain receptors requires a strong cation–π interaction
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2755585
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2755585
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ISSN
0028-0836
E-ISSN
1476-4687,1476-4679
DOI
10.1038/nature07768
