Safety and Efficacy of Autologous CD34+ Hematopoietic Progenitor Cells Transduced with an Anti-Tat R...
Safety and Efficacy of Autologous CD34+ Hematopoietic Progenitor Cells Transduced with an Anti-Tat Ribozyme in a Multi-Center, Randomized, Placebo-Controlled, Phase II Gene Therapy Trial for the Human Immunodeficiency Virus
About this item
Full title
Author / Creator
Mitsuyasu, Ronald T , Merigan, Thomas C , Carr, Andrew , Zack, Jerome A , Winters, Mark A , Workman, Cassy , Bloch, Mark , Lalezari, Jacob , Becker, Stephen , Thornton, Lorna , Akil, Bisher , Khanlou, Homayoon , Finlayson, Robert , McFarlane, Robert , Smith, Don E , Garsia, Roger , Ma, David , Law, Matthew , Murray, John M. , von Kalle, Christof , Ely, Julie A , Patino, Sharon M , Knop, Alison E , Wong, Philip , Todd, Alison V , Haughton, Margaret , Fuery, Caroline , Macpherson, Janet L , Symonds, Geoff P , Evans, Louise A , Pond, Susan M and Cooper, David A
Journal title
Language
English
Formats
More information
Scope and Contents
Contents
Gene transfer has potential as a once-only treatment that reduces viral load, preserves the immune system, and avoids lifetime highly active antiretroviral therapy. This study, the first randomized, double-blind, placebo-controlled, phase II cell-delivered gene transfer clinical trial, was conducted in 74 HIV-1 infected adults who received a
tat...
Alternative Titles
Full title
Safety and Efficacy of Autologous CD34+ Hematopoietic Progenitor Cells Transduced with an Anti-Tat Ribozyme in a Multi-Center, Randomized, Placebo-Controlled, Phase II Gene Therapy Trial for the Human Immunodeficiency Virus
Authors, Artists and Contributors
Author / Creator
Merigan, Thomas C
Carr, Andrew
Zack, Jerome A
Winters, Mark A
Workman, Cassy
Bloch, Mark
Lalezari, Jacob
Becker, Stephen
Thornton, Lorna
Akil, Bisher
Khanlou, Homayoon
Finlayson, Robert
McFarlane, Robert
Smith, Don E
Garsia, Roger
Ma, David
Law, Matthew
Murray, John M.
von Kalle, Christof
Ely, Julie A
Patino, Sharon M
Knop, Alison E
Wong, Philip
Todd, Alison V
Haughton, Margaret
Fuery, Caroline
Macpherson, Janet L
Symonds, Geoff P
Evans, Louise A
Pond, Susan M
Cooper, David A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2768566
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2768566
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.1932
