Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
About this item
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Author / Creator
Barbie, David A. , Tamayo, Pablo , Boehm, Jesse S. , Kim, So Young , Moody, Susan E. , Dunn, Ian F. , Schinzel, Anna C. , Sandy, Peter , Meylan, Etienne , Scholl, Claudia , Fröhling, Stefan , Chan, Edmond M. , Sos, Martin L. , Michel, Kathrin , Mermel, Craig , Silver, Serena J. , Weir, Barbara A. , Reiling, Jan H. , Sheng, Qing , Gupta, Piyush B. , Wadlow, Raymond C. , Le, Hanh , Hoersch, Sebastian , Wittner, Ben S. , Ramaswamy, Sridhar , Livingston, David M. , Sabatini, David M. , Meyerson, Matthew , Thomas, Roman K. , Lander, Eric S. , Mesirov, Jill P. , Root, David E. , Gilliland, D. Gary , Jacks, Tyler and Hahn, William C.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Targeting KRAS cancers
Mutations in genes of the
RAS
family are preset on about 20% of human cancers, making RAS proteins prime potential targets for cancer therapy. Direct targeting of RAS proteins has not so far been productive, but two papers published in this issue offer the prospect of alternative targets in a signalling pathway downs...
Alternative Titles
Full title
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
Authors, Artists and Contributors
Author / Creator
Tamayo, Pablo
Boehm, Jesse S.
Kim, So Young
Moody, Susan E.
Dunn, Ian F.
Schinzel, Anna C.
Sandy, Peter
Meylan, Etienne
Scholl, Claudia
Fröhling, Stefan
Chan, Edmond M.
Sos, Martin L.
Michel, Kathrin
Mermel, Craig
Silver, Serena J.
Weir, Barbara A.
Reiling, Jan H.
Sheng, Qing
Gupta, Piyush B.
Wadlow, Raymond C.
Le, Hanh
Hoersch, Sebastian
Wittner, Ben S.
Ramaswamy, Sridhar
Livingston, David M.
Sabatini, David M.
Meyerson, Matthew
Thomas, Roman K.
Lander, Eric S.
Mesirov, Jill P.
Root, David E.
Gilliland, D. Gary
Jacks, Tyler
Hahn, William C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2783335
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2783335
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature08460
