Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
About this item
Full title
Author / Creator
Glocker, Erik-Oliver , Kotlarz, Daniel , Boztug, Kaan , Gertz, E. Michael , Schäffer, Alejandro A , Noyan, Fatih , Perro, Mario , Diestelhorst, Jana , Allroth, Anna , Murugan, Dhaarini , Hätscher, Nadine , Pfeifer, Dietmar , Sykora, Karl-Walter , Sauer, Martin , Kreipe, Hans , Lacher, Martin , Nustede, Rainer , Woellner, Cristina , Baumann, Ulrich , Salzer, Ulrich , Koletzko, Sibylle , Shah, Neil , Segal, Anthony W , Sauerbrey, Axel , Buderus, Stephan , Snapper, Scott B , Grimbacher, Bodo and Klein, Christoph
Publisher
Waltham, MA: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
Waltham, MA: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
Genetic analyses showed that mutations affecting the interleukin-10 receptor are associated with early-onset colitis. Further molecular analyses showed that the mutations abrogated interleukin-10 signaling. Treatment of one of the affected children by means of allogeneic hematopoietic stem-cell transplantation was successful.
Genetic analyses sh...
Alternative Titles
Full title
Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
Authors, Artists and Contributors
Author / Creator
Kotlarz, Daniel
Boztug, Kaan
Gertz, E. Michael
Schäffer, Alejandro A
Noyan, Fatih
Perro, Mario
Diestelhorst, Jana
Allroth, Anna
Murugan, Dhaarini
Hätscher, Nadine
Pfeifer, Dietmar
Sykora, Karl-Walter
Sauer, Martin
Kreipe, Hans
Lacher, Martin
Nustede, Rainer
Woellner, Cristina
Baumann, Ulrich
Salzer, Ulrich
Koletzko, Sibylle
Shah, Neil
Segal, Anthony W
Sauerbrey, Axel
Buderus, Stephan
Snapper, Scott B
Grimbacher, Bodo
Klein, Christoph
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2787406
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2787406
Other Identifiers
ISSN
0028-4793,1533-4406
E-ISSN
1533-4406
DOI
10.1056/NEJMoa0907206
