PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
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Publisher
National Academy of Sciences
Journal title
Language
English
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Publisher
National Academy of Sciences
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Scope and Contents
Contents
FGF21 is a hormone produced in liver and fat that dramatically improves peripheral insulin sensitivity and lipid metabolism. We show here that obese mice with genetically reduced levels of a key hepatic transcriptional coactivator, PGC-1α, have improved whole-body insulin sensitivity with increased levels of hepatic and circulating FGF21. Gain- and...
Alternative Titles
Full title
PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2799738
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2799738
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0912533106
