structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
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Author / Creator
Auerbach, Tamar , Mermershtain, Inbal , Davidovich, Chen , Bashan, Anat , Belousoff, Matthew , Wekselman, Itai , Zimmerman, Ella , Xiong, Liqun , Klepacki, Dorota , Arakawa, Kenji , Kinashi, Haruyasu , Mankin, Alexander S , Yonath, Ada and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Crystallographic analysis revealed that the 17-member polyketide antibiotic lankacidin produced by Streptomyces rochei binds at the peptidyl transferase center of the eubacterial large ribosomal subunit. Biochemical and functional studies verified this finding and showed interference with peptide bond formation. Chemical probing indicated that the...
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Full title
structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2804743
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2804743
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0914100107
