Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and sig...
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling
About this item
Full title
Author / Creator
Hanker, A B , Mitin, N , Wilder, R S , Henske, E P , Tamanoi, F , Cox, A D and Der, C J
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer and are attractive targets for anti-cancer drug discovery. Rheb is targeted to endomembranes via its C-terminal CAAX (C=cysteine, A=aliphatic, X=terminal amino acid) motif, a substrate for posttranslational modification by a farnesyl isoprenoid. After...
Alternative Titles
Full title
Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2809798
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2809798
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2009.336
