Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR eleme...
Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element
About this item
Full title
Author / Creator
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publication information
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Subjects
More information
Scope and Contents
Contents
How tumour suppressor p53 bifurcates cell cycle arrest and apoptosis and executes these distinct pathways is not clearly understood. We show that
BAX
and
PUMA
promoters harbour an identical MAR element and are transcriptional targets of SMAR1. On mild DNA damage, SMAR1 selectively represses
BAX
and
PUMA
through binding to th...
Alternative Titles
Full title
Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2829167
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2829167
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2009.395
