Improved Induction of Immune Tolerance to Factor IX by Hepatic AAV-8 Gene Transfer
Improved Induction of Immune Tolerance to Factor IX by Hepatic AAV-8 Gene Transfer
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Author / Creator
Publisher
Larchmont, NY: Liebert
Journal title
Language
English
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Publisher
Larchmont, NY: Liebert
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Scope and Contents
Contents
Gene therapy for hemophilia B has been shown to result in long-term expression and immune tolerance to factor IX (F.IX) after in vivo transduction of hepatocytes with adeno-associated viral (AAV-2) vectors in experimental animals. An optimized protocol was effective in several strains of mice with a factor 9 gene deletion (F9(-/-)). However, immune...
Alternative Titles
Full title
Improved Induction of Immune Tolerance to Factor IX by Hepatic AAV-8 Gene Transfer
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Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2829279
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2829279
Other Identifiers
ISSN
1043-0342
E-ISSN
1557-7422
DOI
10.1089/hum.2008.161
