POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation
POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Telomerase contributes to chromosome end replication by synthesizing repeats of telomeric DNA, and the telomeric DNA‐binding proteins protection of telomeres (POT1) and TPP1 synergistically increase its repeat addition processivity. To understand the mechanism of increased processivity, we measured the effect of POT1–TPP1 on individual steps in the...
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Full title
POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2837173
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2837173
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ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2009.409
