G Protein-Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination
G Protein-Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination
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Washington, DC: American Association for the Advancement of Science
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Language
English
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Washington, DC: American Association for the Advancement of Science
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Contents
The myelin sheath allows axons to conduct action potentials rapidly in the vertebrate nervous system. Axonal signals activate expression of specific transcription factors, including Oct6 and Krox20, that initiate myelination in Schwann cells. Elevation of cyclic adenosine monophosphate (cAMP) can mimic axonal contact in vitro, but the mechanisms th...
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Full title
G Protein-Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2856697
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2856697
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1173474
