Essential Role of Fkbp6 in Male Fertility and Homologous Chromosome Pairing in Meiosis
Essential Role of Fkbp6 in Male Fertility and Homologous Chromosome Pairing in Meiosis
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Author / Creator
Crackower, Michael A. , Kolas, Nadine K. , Noguchi, Junko , Sarao, Renu , Kikuchi, Kazuhiro , Kaneko, Hiroyuki , Kobayashi, Eiji , Kawai, Yasuhiro , Kozieradzki, Ivona , Landers, Rushin , Mo, Rong , Hui, Chi-Chung , Nieves, Edward , Cohen, Paula E. , Osborne, Lucy R. , Wada, Teiji , Kunieda, Tetsuo , Moens, Peter B. and Penninger, Josef M.
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
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Scope and Contents
Contents
Meiosis is a critical stage of gametogenesis in which alignment and synapsis of chromosomal pairs occur, allowing for the recombination of maternal and paternal genomes. Here we show that FK506 binding protein (Fkbp6) localizes to meiotic chromosome cores and regions of homologous chromosome synapsis. Targeted inactivation of Fkbp6 in mice results...
Alternative Titles
Full title
Essential Role of Fkbp6 in Male Fertility and Homologous Chromosome Pairing in Meiosis
Authors, Artists and Contributors
Author / Creator
Kolas, Nadine K.
Noguchi, Junko
Sarao, Renu
Kikuchi, Kazuhiro
Kaneko, Hiroyuki
Kobayashi, Eiji
Kawai, Yasuhiro
Kozieradzki, Ivona
Landers, Rushin
Mo, Rong
Hui, Chi-Chung
Nieves, Edward
Cohen, Paula E.
Osborne, Lucy R.
Wada, Teiji
Kunieda, Tetsuo
Moens, Peter B.
Penninger, Josef M.
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2882960
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2882960
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1083022
