Critical Role for α4βδ GABAA Receptors in Shaping Learning Deficits at Puberty in Mice
Critical Role for α4βδ GABAA Receptors in Shaping Learning Deficits at Puberty in Mice
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Author / Creator
Publisher
American Association for the Advancement of Science
Journal title
Language
English
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Publisher
American Association for the Advancement of Science
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Contents
The onset of puberty defines a developmental stage when some learning processes are diminished, but the mechanism for this deficit remains unknown. We found that, at puberty, expression of inhibitory α4βδ γ-aminobutyric acid type A (GABAA) receptors (GABAR) increases perisynaptic to excitatory synapses in CA1 hippocampus. Shunting inhibition via th...
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Full title
Critical Role for α4βδ GABAA Receptors in Shaping Learning Deficits at Puberty in Mice
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2887350
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2887350
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1184245
