Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor
Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor
About this item
Full title
Author / Creator
Aghajanyy, Mariam , Jonai, Nao , Flick, Karin , Fu, Fei , Luo, Manlin , Cai, Xiaolu , Ouni, Ikram , Pierce, Nathan , Tang, Xiaobo , Lomenick, Brett , Damoiseaux, Robert , Hao, Rui , del Moral, Pierre M. , Verma, Rati , Li, Ying , Li, Cheng , Houk, Kendall N. , Jung, Michael E. , Zheng, Ning , Huang, Lan , Deshaies, Raymond J. , Kaiser, Peter and Huang, Jing
Journal title
Language
English
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Scope and Contents
Contents
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control
1
. With prevalent hyper-activation of the mTOR pathway in human cancers
2
, novel strategies to enhance TOR pathway inhibition are highly desirable. We used a yeast-based platform to identify small-molecule enhancers of rapamycin (SMERs) and discovered...
Alternative Titles
Full title
Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor
Authors, Artists and Contributors
Author / Creator
Jonai, Nao
Flick, Karin
Fu, Fei
Luo, Manlin
Cai, Xiaolu
Ouni, Ikram
Pierce, Nathan
Tang, Xiaobo
Lomenick, Brett
Damoiseaux, Robert
Hao, Rui
del Moral, Pierre M.
Verma, Rati
Li, Ying
Li, Cheng
Houk, Kendall N.
Jung, Michael E.
Zheng, Ning
Huang, Lan
Deshaies, Raymond J.
Kaiser, Peter
Huang, Jing
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2902569
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2902569
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.1645
