Reprogramming towards pluripotency requires AID-dependent DNA demethylation
Reprogramming towards pluripotency requires AID-dependent DNA demethylation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Reprogramming of somatic cell nuclei to yield induced pluripotent stem (iPS) cells makes possible derivation of patient-specific stem cells for regenerative medicine. However, iPS cell generation is asynchronous and slow (2–3 weeks), the frequency is low (<0.1%), and DNA demethylation constitutes a bottleneck. To determine regulatory mechanisms inv...
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Full title
Reprogramming towards pluripotency requires AID-dependent DNA demethylation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2906123
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2906123
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature08752
