Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Munc13 primes synaptic vesicles for exocytosis. Studies now reveal that the central C2B domain of Munc13 contains a structurally unusual Ca
2+
binding site that confers specific phospholipid-binding properties to Munc13 and is essential for regulating exocytosis upon trains of action potentials.
Munc13 is a multidomain protein present in p...
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Full title
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2916016
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2916016
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1758
