IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitiv...
IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition
About this item
Full title
Author / Creator
Ropelle, Eduardo R. , Flores, Marcelo B. , Cintra, Dennys E. , Rocha, Guilherme Z. , Pauli, José R. , Morari, Joseane , de Souza, Claudio T. , Moraes, Juliana C. , Prada, Patrícia O. , Guadagnini, Dioze , Marin, Rodrigo M. , Oliveira, Alexandre G. , Augusto, Taize M. , Carvalho, Hernandes F. , Velloso, Lício A. , Saad, Mario J. A. and Carvalheira, José B. C.
Publisher
San Francisco, USA: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
San Francisco, USA: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKβ activation and endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKβ/NF-κB activation by a mechanism dependent upon the pro-inflammatory cytokine interleukin (I...
Alternative Titles
Full title
IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition
Authors, Artists and Contributors
Author / Creator
Flores, Marcelo B.
Cintra, Dennys E.
Rocha, Guilherme Z.
Pauli, José R.
Morari, Joseane
de Souza, Claudio T.
Moraes, Juliana C.
Prada, Patrícia O.
Guadagnini, Dioze
Marin, Rodrigo M.
Oliveira, Alexandre G.
Augusto, Taize M.
Carvalho, Hernandes F.
Velloso, Lício A.
Saad, Mario J. A.
Carvalheira, José B. C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2927536
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2927536
Other Identifiers
ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.1000465
