Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
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Author / Creator
Schlosburg, Joel E , Blankman, Jacqueline L , Long, Jonathan Z , Nomura, Daniel K , Pan, Bin , Kinsey, Steven G , Nguyen, Peter T , Ramesh, Divya , Booker, Lamont , Burston, James J , Thomas, Elizabeth A , Selley, Dana E , Sim-Selley, Laura J , Liu, Qing-song , Lichtman, Aron H and Cravatt, Benjamin F
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Scholsburg and colleagues show that prolonged inactivation of monoacylglycerol lipase, the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol, antagonizes the brain endocannabinoid system. This is manifested as tolerance, impaired plasticity and receptor desensitization; these effects are similar to the effects of prolonged...
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Full title
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2928870
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2928870
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.2616
