Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,8...
Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study
About this item
Full title
Author / Creator
Olmos, David, MD , Postel-Vinay, Sophie, MD , Molife, L Rhoda, MD , Okuno, Scott H, MD , Schuetze, Scott M, MD , Paccagnella, M Luisa, PhD , Batzel, Gretchen N, MD , Yin, Donghua, PhD , Pritchard-Jones, Kathryn, Prof , Judson, Ian, Prof , Worden, Francis P, MD , Gualberto, Antonio, MD , Scurr, Michelle, MD , de Bono, Johann S, Dr and Haluska, Paul, MD
Publisher
England: Elsevier Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: Elsevier Ltd
Subjects
More information
Scope and Contents
Contents
Summary Background Figitumumab is a fully human IgG2 monoclonal antibody targeting the insulin-like growth-factor-1 receptor (IGF-1R). Preclinical data suggest a dependence on insulin-like growth-factor signalling for sarcoma subtypes, including Ewing's sarcoma, and early reports show antitumour activity of IGF-1R-targeting drugs in these diseases....
Alternative Titles
Full title
Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study
Authors, Artists and Contributors
Author / Creator
Postel-Vinay, Sophie, MD
Molife, L Rhoda, MD
Okuno, Scott H, MD
Schuetze, Scott M, MD
Paccagnella, M Luisa, PhD
Batzel, Gretchen N, MD
Yin, Donghua, PhD
Pritchard-Jones, Kathryn, Prof
Judson, Ian, Prof
Worden, Francis P, MD
Gualberto, Antonio, MD
Scurr, Michelle, MD
de Bono, Johann S, Dr
Haluska, Paul, MD
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2941877
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2941877
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(09)70354-7
