Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Telomere shortening, senescence and aging are connected, but how the signal at shortening telomeres is transmitted to the cell more globally is unclear. H3 and H4 synthesis is now shown to be reduced as cell cultures age. This alters expression of Asf1, a histone chaperone, compromising the ability of aging cells to restore chromatin after replicat...
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Full title
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
Authors, Artists and Contributors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2951278
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2951278
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1897
