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Molecular basis for activation of G protein-coupled receptor kinases

Molecular basis for activation of G protein-coupled receptor kinases

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2957210

Molecular basis for activation of G protein-coupled receptor kinases

About this item

Full title

Molecular basis for activation of G protein-coupled receptor kinases

Publisher

Chichester, UK: John Wiley & Sons, Ltd

Journal title

The EMBO journal, 2010-10, Vol.29 (19), p.3249-3259

Language

English

Formats

Publication information

Publisher

Chichester, UK: John Wiley & Sons, Ltd

More information

Scope and Contents

Contents

G protein‐coupled receptor (GPCR) kinases (GRKs) selectively recognize and are allosterically regulated by activated GPCRs, but the molecular basis for this interaction is not understood. Herein, we report crystal structures of GRK6 in which regions known to be critical for receptor phosphorylation have coalesced to stabilize the kinase domain in a...

Alternative Titles

Full title

Molecular basis for activation of G protein-coupled receptor kinases

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2957210

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2957210

Other Identifiers

ISSN

0261-4189,1460-2075

E-ISSN

1460-2075

DOI

10.1038/emboj.2010.206

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